Prostate cancer (PCa) is the most common non-skin cancer in men worldwide. Keywords: prostate size, benign prostate hyperplasia, inverse relationship The results are demonstrating an inverse relationship, and therefore reveal strong evidence that large prostates may be protective of PCa when compared to smaller prostates. In our search, no study was found showing a positive correlation between BPH size and the incidence of PCa.Ĭonclusion: To our knowledge, this is the first systematic review on the important clinical question of interaction between prostate size and the incidence of PCa. Thirty-nine (95%) of the 41 articles showed a statistically significant inverse relationship. Sample sizes ranged from 114 to 6692 patients in these single institutional and multi-institutional studies. Results: Our systematic review found 41 articles reporting an inverse (negative) relationship between prostate gland volume and incidence of prostate cancer. Inclusion and exclusion criteria were defined. Methods: A thorough literature review was performed between through using PubMed and applying the “PRISMA” guidelines. The purpose of this systematic review is to comprehensively summarize studies analyzing any association between prostate gland volume and incidence of PCa. Some studies have reported that larger prostates have a decreased incidence of PCa compared to smaller prostates. Possible causal links between both disease entities are controversially discussed in the current literature. It is well documented that BPH develops in the transition zone (TZ), whereas 80– 85% of PCa originates in the peripheral zone (PZ) of the prostate. Purpose: Prostate cancer (PCa) is the most common non-skin cancer in men worldwide and more than 80% of men with PCa also have histo-anatomical findings of benign prostate hyperplasia (BPH). Department of Urology, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, TX, USAĭepartment of Urology, School of Medicine, Texas Tech University Health Sciences Center, 3601 - 4th Street STOP 7260, Lubbock, TX, 79430, USA
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